Laser-Assisted Photodynamic Therapy (PDT) for Actinic Keratosis (AK), In Situ Squamous Cell Carcinoma (SCC), and Superficial Basal Cell Carcinoma (sBCC)
At KDAA we use laser-assisted photodynamic therapy (PDT) to effectively treat actinic keratosis, surface or in situ squamous cell carcinoma (SCC), and superficial basal cell carcinoma. By combining laser precision with the effectiveness of PDT, this advanced technique enhances treatment outcomes, ensuring higher clearance rates and superior cosmetic results.
How Laser-Assisted PDT Works
- Skin Preparation A minimum of two weeks prior to treatment, daily use of a skin cell exfoliation cosmeceutical (SkinCeuticals Cell Cycle Catalyst) commences.
- Enhanced absorption by sonophoresis Once ALA has been applied to the treatment area ultrasound (Alma Hybrid Impact) is used to push the photosensitising agent deeper into the micro-channels of the skin to enhance clinical outcomes. The treatment area is then occluded, and the patient is placed in a darkened area for 30 – 90 minutes.
- Light Activation After the photosensitiser has been absorbed, the area is exposed to a specific wavelength of light (at KDAA we use Intense Pulse Light – Candela Nordlys IPL), this activates the photosensitiser, producing reactive oxygen species that selectively destroy the abnormal cells.
- Laser Pre-Treatment On the day of treatment an ablative CO2 laser is used to pre-treat the skin, improving the penetration and uptake of the photosensitiser into the targeted lesions by creating micro-channels in the epidermis (top layer of skin).
- Application of Photosensitising Agent A photosensitiser, such as aminolevulinic acid (ALA) or methyl aminolevulinate (MAL), is applied to the skin, this agent is absorbed preferentially by abnormal and precancerous skin cells.
- Post Care On completion of treatment an occlusive ointment is applied and detailed post care instructions are discussed – Note: this treatment can have quite dramatic down time/side effects due to associated inflammation, especially full facial treatment.
Advantages of Laser-Assisted PDT
Precision and Depth Control
- Enhanced Penetration: Laser pre-treatment ensures the photosensitiser reaches deeper into the skin.
- Effective for Resistant Lesions: Particularly beneficial due to enhanced absorption for thicker lesions like in situ SCC and superficial basal cell carcinoma.
- Comprehensive Clearance: Targets both superficial and deeper atypical cells, ensuring thorough treatment, while preserving healthy surrounding tissue.
Higher Clearance Rates:
- Achieves clearance rates of 90-100% for actinic keratosis, significantly higher than traditional PDT.
- Ideal for patients with multiple or recurrent lesions, reducing the likelihood of incomplete treatment or recurrence.
Improved Cosmetic Outcomes
- Minimises the risk of scarring and post-inflammatory hyperpigmentation.
- Preserves surrounding healthy tissue for faster healing and smoother skin post-treatment.
- Particularly beneficial for visible areas like the face, neck, and hands.
Effectiveness Compared to Traditional PDT
- Enhanced Penetration: Ensures even superficial and pre-cancerous lesions are thoroughly treated.
- Fewer Sessions Required:Targets multiple lesions in a single session, improving convenience and reducing treatment burden.
Why Choose Laser-Assisted PDT?
Laser-assisted PDT represents a significant advancement in treating pre-cancerous and superficial skin cancers. It combines:
- Superior Depth Control for effective lesion clearance.
- Higher Efficacy compared to traditional PDT with fewer sessions.
- Aesthetic Benefits, ensuring minimal impact on the skin’s appearance post-treatment.
For individuals seeking effective and patient-friendly treatment for actinic keratosis, in situ SCC, or superficial basal cell carcinoma, laser-assisted PDT offers unmatched results, however there can be quite dramatic down time associated for large area treatments, eg. face, chest. Organise a consult with one of KDAA’s clinical practitioners to answer any questions you have.
